2. Cardiovascular Disease

Cardiovascular Disease

Cardiovascular Disease

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Cardiovascular diseases (CVDs) are the leading causes of death and disability worldwide. CVDs include diseases of the heart, vascular diseases of the brain and diseases of blood vessels. Caused by atherosclerosis, coronary heart disease and cerebrovascular disease are the most common forms of CVDs. Other less common forms of CVDs include rheumatic heart disease and congenital heart disease. A large percentage of CVDs is preventable through the reduction of behavioral risk factors such as tobacco use, physical inactivity and unhealthy diet. Dietary sodium reduction can alleviate the long-term risk of cardiovascular disease events. Statin therapy is an effective intervention in both the primary and secondary preventions of CVDs in those who are at high risk.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-W453397
    Aberrant tau ligand 1 1892461-96-9 ≥98.0%
    Aberrant tau ligand 1 is a tau protein ligand. Aberrant tau ligand 1 engages tau and CRBN to trigger proteasomal degradation. Aberrant tau ligand 1 can be used for synthesis PROTACs, such as QC-01–175 (HY-134850).
    Aberrant tau ligand 1
  • HY-W653809
    Mephentermine hydrochloride 3978-34-5 98.52%
    Mephentermine hydrochloride significantly increases peripheral resistance. Derivatives of mephentermine hydrochloride are inhibitors of MAO-A/B and can be used in cardiovascular research.
    Mephentermine hydrochloride
  • HY-W767164
    Deferiprone O-β-D-glucuronide sodium 98%
    Deferiprone O-β-D-glucuronide sodium is a novel orally active iron chelator. Deferiprone O-β-D-glucuronide sodium can be used to investigate its ability to reduce iron burden in patients with β-thalassemia.
    Deferiprone O-β-D-glucuronide sodium
  • HY-Y0842S1
    Formamide-d3 43380-64-9 99.73%
    Formamide-d3 is the deuterium labeled Formamide (HY-Y0842). Formamide is an effective DNA denaturant that significantly reduces the stability of DNA in buffer solutions. Formamide can also be used as a decalcifying agent for rat cardiac cells. Additionally, formamide is widely used as a solvent or chemical raw material for ion compounds, resins, and plasticizers.
    Formamide-d3
  • HY-Y0882S1
    Hydroxylamine-d3 hydrochloride 15588-23-5 99%
    Hydroxylamine-d3 (hydrochloride) is the deuterium labeled Hydroxyamine hydrochloride. Hydroxylamine hydrochloride is a selective Monoamine oxidase (MAO) inhibitor used for inhibiting of platelet aggregation. Hydroxylamine hydrochloride is an intermediate of nitrogen cycle in aerobic ammonium oxidizers microorganisms, such as ammonium oxidizing bacteria (AOB), ammonium oxidizing archaea (AOA) and complete ammonium oxidizing bacteria (comammox). Hydroxylamine hydrochloride impacts NO and N2O emissions by aerobic ammonium oxidizers microorganisms and inhibits nitrite oxidizing bacteria (NOB) activity.
    Hydroxylamine-d3 hydrochloride
  • HY-W010184S
    4,6-Dioxoheptanoic acid-13C5 881835-86-5 ≥98.0%
    4,6-Dioxoheptanoic acid-13C5 is the 13C labeled 4,6-Dioxoheptanoic acid. 4,6-Dioxoheptanoic acid is a potent inhibitor of heme biosynthesis.
    4,6-Dioxoheptanoic acid-13C5
  • HY-W015600S
    2-Acetamidophenol-d3 122258-87-1 99.48%
    2-Acetamidophenol-d3 (Orthocetamol-d3) is the deuterium labeled 2-Acetamidophenol (HY-W015600). 2-Acetamidophenol (Orthocetamol) is a regulator that targets ferroptosis and glutathione metabolic pathways, is the ortho-regioisomer of Paracetamol (HY-66005). 2-Acetamidophenol has anti-atherosclerotic activity, and inhibiting total cholesterol (TC) and triglyceride (TG) in a zebrafish hyperlipidemia model with IC50s for 30 μM and 40 μM, respectively. 2-Acetamidophenol upregulates the expression of glutathione synthesis-related genes (such as GCLC, GCLM, GSS) and iron ion transport genes (such as FPN1, FTH), reduces the accumulation of intracellular reactive oxygen species (ROS) and ferrous ions (Fe2+), and enhances the activity of glutathione peroxidase GPX4, thereby inhibiting macrophage phagocytosis of oxidized low-density lipoprotein (ox-LDL) and foam cell formation.
    2-Acetamidophenol-d3
  • HY-W016823R
    Tyramine hydrochloride (Standard) 60-19-5 99.69%
    Tyramine (hydrochloride) (Standard) is the analytical standard of Tyramine (hydrochloride). This product is intended for research and analytical applications. Tyramine hydrochloride is an amino acid that helps regulate blood pressure. Tyramine hydrochloride occurs naturally in the body, and it's found in certain foods.
    Tyramine hydrochloride (Standard)
  • HY-15046
    EB-47 366454-36-6 99.89%
    EB-47, a potent and selective PARP-1/ARTD-1 inhibitor with an IC50 value of 45 nM, shows modest potency against ARTD5 with an IC50 value of 410 nM. EB-47 mimics the substrate NAD+ and extends from the nicotinamide to the adenosine subsite.
    EB-47
  • HY-42933
    PDGFR-IN-2 190728-25-7 99.37%
    PDGFR-IN-2 (Compound 16C) is a 4-phenoxyquinoline derivative. PDGFR-IN-2 is a platelet-derived growth factor receptor (PDGFr) inhibitor (IC50: 0.20 μM). PDGFR-IN-2 inhibits the activity of PDGFr tyrosine kinase.
    PDGFR-IN-2
  • HY-50769
    VTP-27999 TFA 1013937-63-7
    VTP-27999 TFA is an alkyl amine Renin inhibitor; VTP-27999 TFA is useful for Hypertension and End-Organ Diseases.
    VTP-27999 TFA
  • HY-B0917
    Bromindione 1146-98-1
    Bromindione is a potent and long-acting, Inandione-derived, oral anticoagulant compound.
    Bromindione
  • HY-B1061
    Nicotinic acid N-oxide 2398-81-4 99.92%
    Nicotinic acid N-oxide can be used for research on hyperlipidemia.
    Nicotinic acid N-oxide
  • HY-B1103
    Hydroxyhexamide 3168-01-2 99.60%
    Hydroxyhexamide is a pharmacologically active metabolite of Acetohexamide, used as a hypoglycemic agents.
    Hydroxyhexamide
  • HY-B1182
    Chromocarb 4940-39-0 99.51%
    Chromocarb is a synthetic vascular protector.
    Chromocarb
  • HY-B1191
    Nanofin 504-03-0 98.0%
    Nanofin (2,6-Lupetidine) is a neuro-blocking agent with antihypertensive effects, which can be used for the study of mild to moderate hypertension.
    Nanofin
  • HY-B2141
    Bendazol 621-72-7
    Bendazol is an orally effective antihypertensive agent. Bendazol acts directly on vascular smooth muscle to dilate blood vessels and reduce peripheral resistance, thereby improving blood circulation. Bendazol significantly inhibits the development of myopia in rabbit models. Bendazol can regulate kidney function by increasing the activity of NO synthase in the rat model of nephrogenic hypertension. In addition, Bendazol has an effect on sexual behavior and spermatogenesis in male rats.
    Bendazol
  • HY-N0333
    Yunaconitine 70578-24-4 99.47%
    Yunaconitine(Guayewuanine B) is a highly toxic aconitum alkaloid.
    Yunaconitine
  • HY-N9279
    Dehydromonocrotaline 23291-96-5 98%
    Dehydromonocrotaline is a mitochondrial respiratory chain complex I NADH oxidase inhibitor, with a IC50 of 62.06 μM and a Ki of 8.1 μM in rats. Dehydromonocrotaline exerts non-competitive inhibitory effects by modifying cysteine thiol groups on complex I, and does not bind to the NADH-binding site. Dehydromonocrotaline dissipates mitochondrial membrane potential and reduces ATP levels. Dehydromonocrotaline can be used in studies related to hepatotoxicity, pulmonary hypertension and liver tumors.
    Dehydromonocrotaline
  • HY-P4279
    Ovalbumin (154-159) 1370698-94-4 99.18%
    Ovalbumin (154-159) is a protein fragment consisting of residues 154-159 of chicken ovalbumin. Ovalbumin (154-159) is also a poorly conserved sequence (Thr-Asn-Gly-Ile-Ile-Arg) in the α-subunit of the Torpedo acetylcholine receptor, located within the α150-164 epitope region, and exhibits significant angiotensin-converting enzyme (ACE) inhibitory activity.
    Ovalbumin (154-159)
Cat. No. Product Name / Synonyms Application Reactivity